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Title: LATE ONSET HEPARIN INDUCED DIC : A RARE CASE

e-poster Number: EP 328

Category: Miscellaneous
Author Name: Dr. Merlyn Joseph
Institute: Shri BM Patil Medical College and research centre, Vijaypura
Co-Author Name:
Abstract :
INTRODUCTION: Heparin induced DIC is a complication of heparin administration that can lead to catastrophic thrombosis. The clinical manifestation usually occurs within 5 to 10 days of starting heparin therapy, but late onset can occur beyond this period, even after heparin is discontinued. In pregnant women, heparin in used for thromboprophylaxis especially in high risk pregnancy conditions. The scenario where heparin is discontinued 24 hours before surgery, and late onset DIC develop, presents challenges both in diagnosing and treating these conditions promptly. CASE REPORT: A 36 year old G3A2 conceived through IVF (Intracytoplasmic sperm injection) with trichorionic-triamniotic gestation with one fetal reduction done at 3 months of amenorrhea with cervical stitch placed insitu was started on heparin for thromboprophylaxis. At 36 weeks growth scan had shown fetus A with severe oligohydramnios and fetus B with mild oligohydramnios and was taken up for cesarean section before which heparin was discontinued 24 hours prior. There was not significant blood loos interoperative bleeding noted. Postoperatively patient developed hematuria and had torrential bleeding per vaginally. Patient was given first line uterotonic drugs and under USG guidance the contents of the uterine cavity was visualized and clots were removed. Protamine sulphate which is heparin neutralizer was given, after which the hematuria gradually reduced and patient recovered. CONCLUSION: Late onset heparin induced DIC is a rare but serious clinical condition, as it can develop after the typical time frame for HIT and may lead to both thrombotic and hemorrhagic complications. In the context of pregnancy, a multidisciplinary approach is essential to balance the risks to both the mother and fetus, including the potential for placental compromise, preterm labor, or hemorrhage. Timely intervention can improve outcomes and reduce the risk of severe complications in both mother and child.