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Introduction ?More than half of the Indian rural women (pregnant and non-pregnant) are anemic. ?There is limited evidence on effectiveness and tolerability of Ferric carboxymaltose (FCM) in Indian rural and tribal women. Aims and Objectives: The primary objective of the present study was to assess the effectiveness of Intravenous (IV) infusion FCM in iron deficiency anemia (IDA) in rural and tribal women. Secondary objectives were to assess change in hematological parameters from baseline and to assess the tolerability. Materials and Methods: A prospective, open-label, observational, real world, single-center study was conducted in which female patients visiting to the Getwell Multispecialty hospital, Manchar, Pune with IDA (Pregnant: Hb 6 to <11 g/dL, non-pregnant: Hb: 6 to <12 g/dl) were recruited. ?FCM was administered (cumulative mean dose: 1009 mg) as an IV infusion and patients were followed-up at 6 weeks. ?Change in the Hb, other hematological parameters from baseline were assessed. Adverse effects related to FCM were monitored. Results: 55 patients completed the study. 7.27% and 92.73% of the patients were pregnant and non-pregnant respectively. Significant increase in Hb of 3.64 g/dL was recorded at 6 weeks. All pregnant women achieved the target Hb of 11 g/dL, while 58.82% of non-pregnant women reached 12 g/dL; there was a significant increase in hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration ?(P < 0.05 for all) as compared to baseline. FCM infusion was well tolerated. Conclusions ?FCM IV infusion significantly increased Hb levels and also significantly improved other haematological parameters at 6 weeks. FCM appears to be effective and well-tolerated treatment for IDA in pregnant and non-pregnant women in rural and tribal area.