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Title: HORMONAL SHIFTS AND MENOPAUSAL STRUGGLES: THE FSH-ESTRADIOL LINK IN INDIAN WOMEN
e-poster Number: EP 442
Category: Miscellaneous
Author Name: Dr. Sandnya Sukhatme
Institute: Bombay hospital institute of medical sciences
Co-Author Name:
Abstract :
Introduction ? As FSH levels rise during menopause, its impact on symptom severity and metabolic function remains insufficiently explored. This study aims to investigate the relationship between FSH, E2 levels, and the severity of menopausal symptoms, focusing on how these hormonal changes affect symptom intensity in Indian women. Aims and Objectives ? This study aims to investigate the association between circulating FSH levels and the severity of menopausal symptoms in Indian women, as well as its correlation with metabolic risk factors in both menopausal and non-menopausal women. Materials and Methods ? The study is a cross-sectional design, including women aged 40 years and above, Postmenopausal and premenopausal women, with or without menopausal symptoms. Written informed consent was obtained from all participants. The Menopause Rating Scale (MRS) was used to categorize symptoms into five groups: none, mild, moderate, severe, and very severe. Serum FSH and estradiol were measured using the chemiluminescence method. Statistical correlations between symptom severity and FSH/E2 levels were analyzed using IBM SPSS software. Results ? The mean age of menopausal women was 53 years, with median FSH and E2 levels of 69 IU/L and 28 pg/mL, respectively, compared to non-menopausal women, whose mean age was 47 years with median FSH and E2 levels of 6 IU/L and 128 pg/mL. Among menopausal women, symptoms were mild (8), moderate (8), severe (3), and none (4). Non-menopausal women experienced fewer symptoms, with no severe cases observed. Severe symptoms in menopausal women correlated with higher FSH levels (61-80 IU/L) and lower E2 levels (31-60 pg/mL). Conclusion ? Elevated FSH and reduced estradiol levels in menopausal women correlate with increased symptom severity. These findings highlight the need for further research on FSH?s role in symptom severity and its connection to metabolic and cardiovascular risk factors, which may lead to better management strategies for menopausal women.
