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ISOLATED GENITAL TUBERCULOSIS: A RARE CAUSE OF PREMATURE OVARIAN FAILURE AUTHOR : DR C.SNEHA REDDY 2ND YEAR PG GUIDE : DR.P.SUDHIR BABU,MD,PROFESSOR AND HOD OF OBG,SVS MEDICAL COLLEGE,MAHABUBNAGAR,TELANGANA Introduction: Latent genital tuberculosis infection (LGTBI) can damage upper genital tract which may lead to premature ovarian failure and infertility. Literature shows that LGTBI shows a correlation with low anti-M?llerian hormone (AMH) levels proves its role in ovarian reserve depletion,ovarian damage and premature ovarian failure. This case asserts the importance of early diagnosis which is difficult due to lack of obvious clinical and radiological signs which ultimately results in Premature Ovarian Failure (POF). Case Presentation: A 35-year-old female patient presented with the secondary amenorrhea for 18months, persistent fatigue, and diffuse tinea corporis not responding to the antifungal treatment. Investigations showed an increased follicle-stimulating hormone (FSH) and decreased anti-M?llerian hormone (AMH) levels, indicating a diminished ovarian reserve. Transvaginal ultrasonography revealed atrophic features in both ovaries without showing hydrosalpinx, adnexal mass, and abnormalities in endometrium. Endometrial biopsy doesn?t reveal any granulomatous inflammation or acid-fast bacillus. Polymerase Chain Reaction (PCR) on endometrial tissue emerged positive for Mycobacterium tuberculosis, confirming latent genital TB. Discussion: The patient was kept on anti tuberculosis therapy and her tinea corporis rapidly improved within a few weeks, suggesting tuberculosis's immunomodulatory effect as a cause of tinea.But there was no signs of recovery regarding ovarian function due to irreversible damage likely by prolonged inflammation or fibrosis due to latent infection. This case emphasise that FGTB is cause of unexplained infertility in many parts of developing countries like India. Conclusion Early identification and treatment may reverse or check the damage to ovaries and preserve the fertility.There is a need to understand the mechanisms by which FGTB affects ovarian function which may help to develop right strategies for fertility preservations.