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Title: DOES BASAL LH AFFECT OUTCOMES OF COS CYCLES IN PCOS PATIENTS?
A RETROSPECTIVE MULTICENTRIC OBSERVATIONAL STUDY
e-poster Number: EP 463
Category: Infertility Diagnosis and Treatment
Author Name: Dr. Sandhya Deepika Oruganti
Institute: FERTY9 FERTILTY CENTER
Co-Author Name:
Abstract :
Aim:
To evaluate the influence of basal luteinizing hormone (bLH) levels on controlled ovarian stimulation (COS) outcomes in women with polycystic ovary syndrome (PCOS) undergoing the GnRH-antagonist stimulation protocol.
Methods:
This retrospective multicentric study included 100 PCOS patients undergoing IVF/ICSI using the GnRH-antagonist protocol between January 2024 and September 2024. Patients were divided into two groups based on bLH levels: Group 1 (bLH < 10 IU/L) and Group 2 (bLH ? 10 IU/L). The primary outcome assessed was the number of blastocysts formed. Secondary outcomes included the total gonadotropin dose, the number of oocytes retrieved, the number of metaphase II (M2) oocytes, the number of fertilized oocytes, and the number of Day 3 embryos formed.
Results:
Preliminary analysis indicates no significant differences in COS outcomes between the two groups. No of blastocycts obtained is slightly higher in the group 1 patients but it is not statistically significant (p>0.05).There is no significant difference in the total gonadotropin dose the number of oocytes retrieved, the number of metaphase II (M2) oocytes, the number of fertilized oocytes, and the number of Day 3 embryos formed (p >0.05). Detailed results are presented for each outcome measure.
Conclusion:
Basal LH levels (<10 IU/L vs. ?10 IU/L) do not significantly impact COS outcomes in PCOS patients undergoing the GnRH-antagonist protocol. These findings suggest that bLH levels may not serve as a critical predictor for tailoring stimulation protocols in PCOS patients. Further studies with larger sample sizes are recommended for validation.
