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INTRODUCTION Systemic lupus erythematosus (SLE) in pregnancy poses high risks, including preeclampsia and preterm birth. Multidisciplinary management and careful monitoring can improve outcomes, reducing disease flares and enhancing maternal and fetal health. AIMS AND OBJECTIVE The aim is to optimize pregnancy outcomes in women with SLE by minimizing disease activity and managing complications. Objectives include regular monitoring, multidisciplinary care, controlling flares, and reducing risks like preeclampsia and fetal growth restriction for maternal-fetal health. MATERIAL AND METHODS This single-case study involves a 32-year-old pregnant woman with a 5-year history of SLE. Data collection included her medical history, medication regimen (hydroxychloroquine, prednisone), and disease status pre-conception. Regular clinical assessments, including blood pressure, joint exams, kidney function, and lupus activity markers, were conducted. Fetal growth was monitored biweekly through ultrasound, and low-dose aspirin was prescribed to prevent preeclampsia. A multidisciplinary team managed her care, with adjustments to medications as necessary. The outcome was recorded and analyzed to assess maternal and fetal health. RESULTS The patient experienced mild hypertension at 20 weeks and an SLE flare at 28 weeks, presenting with joint pain and proteinuria. Treatment adjustments included increasing prednisone and initiating low-dose aspirin for preeclampsia prevention. Biweekly fetal growth scans showed no abnormalities. At 36 weeks, labor was induced due to preeclampsia, resulting in the birth of a healthy infant. Postpartum, her SLE symptoms gradually improved with medication adjustments. This case demonstrates effective management of SLE in pregnancy, achieving a favorable maternal and fetal outcome. CONCLUSION This case highlights the importance of vigilant, multidisciplinary management of SLE in pregnancy. With close monitoring and timely adjustments to treatment, complications such as hypertension, SLE flares, and preeclampsia were managed effectively, resulting in a healthy delivery. This approach emphasizes the need for individualized care to optimize both maternal and fetal outcomes in high-risk pregnancies. Such cases underscore the potential for successful pregnancies in women with SLE when proactive, tailored care is provided.