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Title: RETROSPECTIVE STUDY OF THYROID ABNORMALITIES AND CORRELATION WITH GESTATIONAL AGE AT BIRTH
e-poster Number: EP 408
Category: Maternal and Fetal Health
Author Name: Dr. Sana Shaikh
Institute: Seth GS Medical College
Co-Author Name:
Abstract :
Introduction -Hypothyroidism occurs in about 1% of pregnant women and is usually due to autoimmune Hashimoto's thyroiditis or due to dietary iodine deficiency.Diagnosis of clinical (overt) hypothyroidism is made by abnormally high serum thyrotropin level (TSH) accompanied by abnormally low thyroxine level (free T3 and T4). Subclinical hypothyroidism is defined as abnormally high serum thyrotropin (TSH) level with normal thyroxine.Both subclinical and overt hypothyroidism can be associated with adverse pregnancy outcomes, including preterm birth (delivery before 37 weeks of gestation).While the association between maternal hypothyroidism and preterm birth has been recognized, the underlying mechanisms and extent of this relationship require further exploration. Methodology-This is a retrospective study conducted in 500 pregnant women delivering at a tertiary care hospital. Exclusion criteria-1)Females with other pregnancy complications like gestational hypertension,Gestational Diabetes,Congenital anomalies 2)Females undergoing preterm Deliveries due to any other maternal or fetal indication Sample size -500 The data on maternal demographics, thyroid hormone levels, gestational age at delivery, and neonatal outcomes collected using hospital records.Women divided into two groups A)With Subclinical or Overt hypothyroidism B)Control group of Women with Euthyroid state. Statistical analysis was performed to evaluate the correlation between maternal hypothyroidism and gestational age at the time of delivery, with adjustments for potential confounding factors such as maternal age, comorbidities, and history of preterm deliver Objective- 1.To evaluate the correlation between maternal thyroid hormone levels and the risk of preterm delivery. 2.To compare pregnancy and neonatal outcomes in hypothyroid and euthyroid women. Results-Studies have shown positive corelation between hypothyroidism and preterm labour Observational studies, although limited, indicate that excessive adverse perinatal outcomes are associated with overt T4 deficiency . Study conducted by sheehan et al have shown incresed incidence of preterm labour in Hypothyroidism.