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Title: YOLK SAC TUMOUR : A RARE MALIGNANT OVARIAN TUMOUR ? A CASE REPORT.

e-poster Number: EP 145

Category: Gynaecologic Oncology
Author Name: Dr. Manjusri N
Institute: Assam Medical College, Dibrugarh
Co-Author Name:
Abstract :
Introduction Yolk sac tumors, also known as endodermal sinus tumors, are rare malignant germ cell tumors resembling the primitive yolk sac's mesenchymal structures. They can occur as pure forms or mixed with other germ cell tumors and constitute 14?20% of all malignant ovarian germ cell tumors (OGCTs). Early diagnosis and management are crucial for optimizing outcomes. Case Details An 18-year-old female presented with a four-month history of an abdominal lump and one month of abdominal pain. Clinical evaluation revealed a mass of approximately 24-week size arising from the left adnexa. Routine blood investigations were unremarkable. Pelvic ultrasound identified a well-defined, solid tumor in the left adnexa measuring 15 ? 10 ? 10 cm with solid-cystic components and minimal ascites. Tumor markers were elevated: serum Ca-125 at 22.85 U/mL, beta-hCG at 3 U/mL, LDH at 800 U/L, and AFP >400 U/mL. The patient underwent exploratory laparotomy. Intraoperatively, a 15 ? 14 ? 13 cm ovarian mass with tortuous vessels, omental nodules, and peritoneal deposits was observed. A left-sided salpingo-oophorectomy, infracolic omentectomy, and peritoneal toileting were performed. The tumor was staged as FIGO Stage IIIC ovarian malignancy. Histopathological examination confirmed the diagnosis of a yolk sac tumor. The patient was referred to oncology for chemotherapy. Discussion Yolk sac tumors are aggressive germ cell malignancies often diagnosed in young women. The primary treatment involves surgical resection, followed by platinum-based chemotherapy. Elevated AFP is a key diagnostic marker, while imaging aids in assessing tumor extent. Early and comprehensive management significantly impacts prognosis, though Stage IIIC disease often indicates advanced spread with variable outcomes. Conclusion This case highlights the importance of recognizing clinical signs of ovarian malignancy in young females. Timely surgical intervention, histopathological evaluation, and adjunct chemotherapy are essential for improving survival in yolk sac tumors.