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Title: MALIGNANT MIXED MULLERIAN TUMOR OF ENDOMETRIUM- A RARE ENTITY.
e-poster Number: EP 255
Category: Gynaecologic Oncology
Author Name: Dr. Jil Bhavin Kadakia
Institute: Bombay Hospital Institute of Medical Sciences
Co-Author Name:
Abstract :
Malignant Mixed Mullerian Tumor of Endometrium- A Rare Entity. Introduction: Malignant Mixed Mullerian Tumor (MMMT) (uterine carcinosarcoma) is an uncommon and a highly aggressive neoplasm arising from the female reproductive organs- uterus, ovary, fallopian tube and vagina. Of these, uterine corpus involvement is the most common. It frequently affects postmenopausal women. It has been recently regarded as high grade de-differentiated endometrial carcinoma. Histologically, uterine MMMT is a biphasic neoplasm that is composed of malignant epithelial and mesenchymal components. The incidence of uterine MMMT is 2 per 100,000 women per year, accounting for about 2-5 % of all uterine malignancy. Because of its rarity, there is no standardised treatment protocol. Surgery remains the mainstay of treatment. Adjuvant therapies like radiation and chemotherapy have been tried to improve survival. Despite all these efforts, the 5-year overall survival rate is between 33%-39%. There are very few reports discussing the outcomes of this tumor in our setup. Here we present case of 74 year old postmenopausal woman with complaints of postmenopausal bleeding, diagnosed as uterine MMMT. Aims & Objectives: Case description and report of a rare gynaecological malignancy, it?s management, follow-up and prognosis as it as very rare tumor with no standardised treatment protocol. Materials & Methods: Patient presented to OPD with complaints of postmenopausal bleeding. She was admitted for further evaluation and operative laparoscopy done following preanaesthetic check. Results: Intraoperative frozen section suggestive of endometrial malignancy. Histopathology report confirmed MMMT of endometrium. Conclusion: MMMT is a very rare and aggressive tumor. It is a biphasic neoplasm having malignant epithelial and mesenchymal components. Due to its rarity, there is no standardised treatment protocol. Outcome depends upon the stage of disease and depth of tumor invasion.