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Title: BORDERLINE BRENNER TUMOUR OF OVARY IN A YOUNG WOMAN : A CASE REPORT
e-poster Number: EP 314
Category: Gynaecologic Oncology
Author Name: Dr. Sweta Sinha
Institute: ESIC Bihta
Co-Author Name:
Abstract :
Introduction - Brenner tumour of ovary is an uncommon tumour with only about 30 case reports in the English literature to date.Brenner tumours of the ovary constitute 1% to 2% of all ovarian neoplasms.The average age at presentation is 50years with 71% of the patient being more than 40years.They are mostly benign and unilateral.Borderline and malignant forms are much rarer. Case report- A 30years old, nulliparous lady presented with abdominal distension and irregular menses for 3 months.She underwent right salpingo-oophorectomy and omentectomy for a huge ovarian mass. Grossly, the tumour is encapsulated and display greyish smooth external surfaces.Serial cut sections showed tan to yellowish firm solid cystic appearance, predominantly solid in areas.Microscopically, the tumour is composed of epithelial nests arranged in a background of dense fibromatous stroma.These epithelial cells display fairly uniform oval nuclei with longitudinal nuclear grooves, distinct nucleoli, with moderate to abundant eosinophilic cytoplasm. The epithelial cell nests are immunoreactive for cytokeratin(CK)7 and p63; negative for CK 20, calretinin, WT-1, CD10, desmin, SMA, caldesmon, S100, CD34, ER and PR, Ki67 proliferative index is very low(<2%). Discussion- The major considerations for this case were benign Brenner tumour with stroma l overgrowth or ovarian fibroma with minor sex cord component. In our case, the macroscopy findings were suggestive of an ovarian fibroma, showing a solid and firm cut surfaces.The presence of epithelial nests amidst abundant fibrous stroma on histology also suggested an ovarian fibroma with minor sex cord components as a potential differential diagnosis. Conclusion- Borderline Brenner tumour of ovary is a relatively uncommon entity.The histomorphology with the aid of immunohistochemical stains are crucial in the diagnosis of this uncommon tumour.